ea0034p178 | Neoplasia, cancer and late effects | SFEBES2014
Poole Vikki Louise
, Read Martin
, Watkins Rachel
, Modasia Bhavika
, Ryan Gavin
, Boelaert Kristien
, Franklyn Jayne
, Smith Vicki
, McCabe Christopher
Whilst, radioiodine ablation is an effective therapy for many patients with thyroid cancer, a subset of patients are incapable of accumulating sufficient iodide-131 for effective treatment, due to low sodium–iodide symporter (NIS) activity. Previous work has identified that the overexpression of pituitary tumor transforming gene (PTTG) binding factor (PBF) in thyroid cells leads to the redistribution of NIS from the plasma membrane into intracellular vesicles, thereby red...